The paper is a contribution to more effective using of simulation optimization. The article presents the results of the comparison study of selected algorithms of simulation optimization. The authors have tested several algorithms on various simulation models. The simulation models of systems were created in simulator Witness. The main goal was to give the general procedure for effective usage of simulation optimization. The authors point out that the realization of simulation optimization is a compromise between acceptable time and accuracy of found solution. The final procedure involves the process of selection of algorithm, input variables, their set up of range, step selection. The proposal of the authors has already been realized and has brought significant time reduction.