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This paper presents a case study on organization of pre-trip route planning and clustering for sales activity. Pre-trip route planning is a standard service of intelligent transportation systems (ITS). The study observed the territory of the Republic of Croatia which is represented with historical data for16 515 points of sales. The solution should discover the number of sales regions, number of salesmen per region and planned routes for a single month. Constraints and input data are derived from real life points of sales data like sales potentials, geographic position and maximum number of customers for each route.